| Top Holders
| | | Shares Held | % O/S | Share Change | Filing Date | | Novartis AG | 31,324,187 | 43.0 | 9,245 | 06/08/10 | | T. Rowe Price Associates, Inc. | 8,101,442 | 11.1 | 4,719,642 | 04/30/10 | | MPM Capital, L.L.C. | 3,321,534 | 4.6 | 0 | 03/31/10 | | Sommadossi (Jean-Pierre) | 2,219,754 | 3.1 | 0 | 04/01/10 | | Adage Capital Management, L.P. | 2,065,835 | 2.8 | 450,000 | 03/31/10 | | BlackRock Institutional Trust Company, N.A. | 1,689,013 | 2.3 | -35,608 | 03/31/10 | | Columbia Wanger Asset Management, L.P. | 1,664,300 | 2.3 | 1,664,300 | 05/31/10 | | Vanguard Group, Inc. | 1,444,415 | 2.0 | 18,839 | 03/31/10 | | Putnam Investment Management, L.L.C. | 960,567 | 1.3 | 275,832 | 03/31/10 | | Dimensional Fund Advisors, LP | 587,325 | 0.8 | -8,133 | 03/31/10 |
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